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During treatment initiation and dose titrationsee belowone-hour postprandial plasma glucose may be used to determine the therapeutic response to PRECOSE and identify the minimum effective dose for the patientThereafterglycosylated hemoglobin should be measured at intervals of approximately three monthsThe therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of PRECOSEeither as monotherapy or in combination with sulfonylureasinsulin or metformin.
Know the signs of low blood sugarhypoglycemiaand how to recognize themheadachehungerweaknesssweatingtremorsirritabilityor trouble concentrating.
Caution with drugs that cause hyperglycemiaegdiureticssteroidsestrogensphenothiazinesthyroid productsphenytoinniacinsympathomimeticscalcium channel blockersisoniazidAntagonized by intestinal adsorbentsegcharcoalpancreatinamylaseother carbohydrate-splitting enzymesMonitor digoxinand for hypoglycemia if used with insulin or a sulfonylureaMay result in unreliable measurements of 1,5-AG assayuse alternative methods to monitor glycemic control.
Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydratesthereby resulting in a smaller rise in blood glucose concentration following mealsAs a consequence of plasma glucose reductionPrecose reduces levels of glycosylated hemoglobin in patients with type 2 diabetes mellitusSystemic non-enzymatic protein glycosylationas reflected by levels of glycosylated hemoglobinis a function of average blood glucose concentration over time.
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