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To investigate the target of ogf as to cell proliferation, the effects of excess ogf, and a deprivation of ogf-ogfr interaction by an opioid antagonist, naltrexone ntx , were examined in 3 human cancer cell lines pancreatic bxpc-3 , colon ht-29 , and head and neck cal-27 .

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Naltrexone appears to have extra-hepatic sites of drug metabolism and its major metabolite undergoes active tubular secretionsee Metabolism aboveAdequate studies of naltrexone in patients with severe hepatic or renal impairment have not been conductedsee PRECAUTIONSSpecial Risk Patients

REVIA should be considered as only one of many factors determining the success of treatment of alcoholismFactors associated with a good outcome in the clinical trials with REVIA were the typeintensityand duration of treatmentappropriate management of comorbid conditionsuse of community-based support groupsand good medication complianceTo achieve the best possible treatment outcomeappropriate compliance-enhancing techniques should be implemented for all components of the treatment programespecially medication compliance.

In a situation requiring opioid analgesiathe amount of opioid required may be greater than usualand the resulting respiratory depression may be deeper and more prolonged.

When coadministered with morphineon a chronic basisREVIA blocks the physical dependence to morphineheroin and other opioids.

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