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Avoid drinking alcohol, which can increase some of the side effects of hydrochlorothiazide and triamterene.
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Thiazides may add to or potentiate the action of other antihypertensive drugs.
Triamterene is rapidly absorbed following oral administrationPeak plasma levels are achieved within one hour after dosingTriamterene is primarily metabolized to the sulfate conjugate of hydroxytriamtereneBoth the plasma and urine levels of this metabolite greatly exceed triamterene levels.
MAXZIDE is contraindicated in patients with anuriaacute and chronic renal insufficiency or significant renal impairment.
Potassium-conserving therapy should also be avoided in severely ill patients in whom respiratory or metabolic acidosis may occurAcidosis may be associated with rapid elevations in serum potassium levelsIf MAXZIDE is employedfrequent evaluations of acid/base balance and serum electrolytes are necessary.
The exact mechanism of hydrochlorothiazide’s antihypertensive action is not known although it may relate to the excretion and redistribution of body sodium.
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triamterene belongs to the class of organic compounds known as pteridines and derivatives.