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Topiramate is most useful for people who have bipolar mood disorders that other mood stabilizers have been unable to controlIt can relieve symptoms and make taking antidepressants possible for people who ere unable to take them before without experiencing mania or a mixed stateTopiramate has a favorable side effect profile and up to half of all people who take the drug experience weight lossThis is a beneficial counteraction to the weight gain that many antidepressants can cause.

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researchers noted that all patients included in the trial had been diagnosed with episodic migraines and previously underwent initial monotherapy treatment with either topamax 100 mg day or nortriptyline 30 mg day for 8 weeks and derived inadequate symptomatic relief.

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