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Along with its needed effectsezetimibe/simvastatin may cause some unwanted effectsAlthough not all of these side effects may occurif they do occur they may need medical attention.
The most common adverse reactions in the group treated with VYTORIN that led to treatment discontinuation and occurred at a rate greater than placebo were:
It is very important to continue to follow your doctor’s advice about diet and exerciseIt may take up to 4 weeks before you get the full benefit of this drug.
Fenofibrates may increase cholesterol excretion into the bileleading to cholelithiasisIn a preclinical study in dogsezetimibe increased cholesterol in the gallbladder bilesee Animal PharmacologyIf cholelithiasis is suspected in a patient receiving VYTORIN and a fenofibrategallbladder studies are indicated and alternative lipid-lowering therapy should be consideredsee the product labeling for Fenofibrate And Fenofibric Acid
Ezetimibe and simvastatin can cause the breakdown of muscle tissuewhich can lead to kidney failureThis happens more often in womenin older adultsor in people who have kidney disease or poorly controlled hypothyroidismunderactive thyroid
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if the dose of vytorin is changed or discontinued, the same procedure should be repeated.