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Findings in clinical trialshoweverare not known to reliably predict the abuse potential of drugsNonethelessevidence from single-dose studies does suggest that the recommended daily dosage of bupropion when administered in divided doses is not likely to be especially reinforcing to amphetamine or stimulant abusersHoweverhigher doses that could not be tested because of the risk of seizure might be modestly attractive to those who abuse stimulant drugs.

MusculoskeletalInfrequent were leg crampsAlso observed were muscle rigidity/fever/rhabdomyolysis and muscle weakness.

Bupropion may cause seizuresespecially in people with certain medical conditions or when using certain drugsTell your doctor about all of your medical conditions and the drugs you use.

Many drugs can interact with bupropionTell your doctor about all medicines you useand those you start or stop using during your treatmentThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.

You should not change your dose or stop using bupropion suddenlyunless you have a seizure while taking this medicineStopping suddenly can cause unpleasant withdrawal symptoms.

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