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In cas mono-bonchodilatthapy dos not contol symptoms COPD adquatly i gula maintnanc thapy is dsid, a thaputic intvntion with a combination bonchodilatos is commndd. Th isks sid-cts incass with incasing dos any dug and, tho, th most impotant ational combination thapy is a vy avouabl atiicacy and saty. Knowing that anticholingic and bta-adngic agnts achiv thi bonchodilating cts by dint mchanisms, in paticula th combination ths agnts has povn tb bnicial in th managmnt COPD. Basd on th stablishd clinical bnits, tiotopium is an attactiv and pomising agnt th ist-lin long-tm maintnanc thapy in COPD. This alsimplis that a thaputic intvntion with oth bonchodilatos will b pscibd in daily pactic. At psnt nstudis on combination thapy with shot-acting agnts a availabl. Tho, using a doubl-blind, andomisd, cossov dsign, th bonchodilatcts singl doss ipatopium notol w compad with placbwhn addd on top stady stat tiotopium. Patints w p-tatd with tiotopium tachiv this phamacodynamic stady stat. Sial lung unction tsts (V1, VC, aw, sGaw) w conductd ollowing add-on th shot-acting bonchodilatos placbo.

Th toxicity ipatopium bomid has bn invstigatd xtnsivly in th ollowing typs studis: acut, subchonic and chonic toxicity, cacinognicity, poductiv toxicity and mutagnicity via oal, intavnous, subcutanous, intanasal and/inhalation outs. Basd on ths toxicity studis, th pobability systmic anticholingic sid cts dcass in th ollowing od:

Th inomation povidd on this sit is gnal inomation and ducational puposs only. You should always consult a doctdiagnosing and tating a halth itnss poblm, and busing any dug poduct discussd on this sit.

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