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You may be advised to take calcium and vitamin D supplements to help prevent bone lossWeight bearing exercise and a healthy diet rich in calcium and vitamin D can also help protect your bone healthYour doctor will check your bone health before starting therapyThis is done with a bone density scanDEXA scanWomen with no weakening of bones prior to aromatase inhibitor therapy will have a follow-up scan around one year after starting therapyand then every one to two yearsIf the scan shows that you already have some bone weakeningyour doctor may order a type of medication called a bisphosphonateThese therapies have been shown to protect the bones from bone loss in women taking aromatase inhibitorsIf the bone density remains stablescans can then be done every two years.

In the United Statesthe labeling of letrozole already warned that it had been associated with birth defectsNovartis has never sought FDA approval to market letrozole as a fertility medication and was clearly concerned about their liability if given in pregnancy.

Letrozole is a medication that is metabolized rapidly in the bodyIt is not thought to have significant levels in the blood or tissues for a prolonged period of time.

Letrozole can pass into body fluidsurinefecesvomitCaregivers should wear rubber gloves while cleaning up a patient’s body fluidshandling contaminated trash or laundry or changing diapersWash hands before and after removing glovesWash soiled clothing and linens separately from other laundry.

This medication can cause fatiguedizzinessand somnolenceYou should not drive or operate heavy machinery until you know how this medication will affect you.

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