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Gefitinib major monitor for an increased incidence of gefitinib-related adverse effects if gefitinib and isoniazid, inh are used concomitantly.

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Isoniazid is a prodrug and must be activated by bacterial catalaseSpecficiallyactivation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complexOnce activatedisoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallAt therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organismsSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

Antibacterial agent used primarily as a tuberculostaticIt remains the treatment of choice for tuberculosisPubChem]

Along with its needed effectsisoniazid may cause some unwanted effectsAlthough not all of these side effects may occurif they do occur they may need medical attention.

Before taking isoniazidtell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

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