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The following adverse reactions have been reported in patients receiving marketed KEPPRA worldwideThe listing is alphabetizedabnormal liver function testacute kidney injuryanaphylaxisangioedemaagranulocytosischoreoathetosisdrug reaction with eosinophilia and systemic symptomsDRESSdyskinesiaerythema multiformehepatic failurehepatitishyponatremiamuscular weaknesspancreatitispancytopeniawith bone marrow suppression identified in some of these casespanic attackthrombocytopeniaand weight lossAlopecia has been reported with KEPPRA userecovery was observed in majority of cases where KEPPRA was discontinued.
Suicidesuicide attemptsuicidal ideation and behaviour have been reported in patients treated with anti-epileptic agentsincluding levetiracetamA meta-analysis of randomized placebo-controlled trials of anti-epileptic medicinal products has shown a small increased risk of suicidal thoughts and behaviourThe mechanism of this risk is not known.
Available data in children did not suggest impact on growth and pubertyHoweverlong term effects on learningintelligencegrowthendocrine functionpuberty and childbearing potential in children remain unknown.
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