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Single-dose studies with micronase tablets in normal subjects demonstrate significant absorption of glucovance mite within 1 hour, peak drug levels at about 4 hours, and low but detectable levels at 24 hours.
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Common side effects include nauseaheartburnrasheslow blood sugarblurred vision and weight gainRare but serious side effects include hepatitisjaundiceand low blood sodium levelshyponatremia
Elderly patients are particularly susceptible to the hypoglycemic action of glucose lowering drugsHypoglycemia may be difficult to recognize in the elderlysee PRECAUTIONSThe initial and maintenance dosing should be conservative to avoid hypoglycemic reactionssee DOSAGE AND ADMINISTRATION
There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with MICRONASE or any other anti-diabetic drug.
Read the Patient Information Leaflet if available from your pharmacist before you start taking glyburide and each time you get a refillIf you have any questionsask your doctor or pharmacist.
Bosentan because liver problems may occur and the effectiveness of both medicines may be decreased Beta-blockersegpropranololbecause the risk of low blood sugar may be increasedThey may also hide certain signs of low blood sugar and make it more difficult to notice Angiotensin-converting enzymeACEinhibitorsegenalaprilanticoagulantsegwarfarinazole antifungalsegketoconazolemiconazolechloramphenicolclarithromycinclofibratedisopyramidefenfluraminefluoxetineinsulinmonoamine oxidase inhibitorsMAOIsegphenelzinenonsteroidal anti-inflammatory drugsNSAIDsegibuprofenphenylbutazoneprobenecidquinolone antibioticsegciprofloxacinsalicylatesegaspirinor sulfonamidesegsulfamethoxazolebecause the risk of low blood sugar may be increased Calcium channel blockersegdiltiazemcorticosteroidsegprednisonedecongestantsegpseudoephedrinediazoxidediureticsegfurosemidehydrochlorothiazideestrogenshormonal contraceptivesegbirth control pillshydantoinsegphenytoinisoniazidniacinphenothiazinesegpromethazinerifamycinsegrifampinsympathomimeticsegalbuterolepinephrineterbutalineor thyroid supplementseglevothyroxinebecause they may decrease Micronase’s effectivenessresulting in high blood sugar Gemfibrozil because blood sugar may be increased or decreased Cyclosporine because the risk of its side effects may be increased by Micronase.
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