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TOPROL-XL is indicated for the treatment of stablesymptomaticNYHA Class II or IIIheart failure of ischemichypertensiveor cardiomyopathic originIt was studied in patients already receiving ACE inhibitorsdiureticsandin the majority of casesdigitalisIn this populationTOPROL-XL decreased the rate of mortality plus hospitalizationlargely through a reduction in cardiovascular mortality and hospitalizations for heart failure.

If you forget to take a dose of TOPROL-XLskip the dose you missed and take your next dose when you are meant to.

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thus, this trial extends the time over which carvedilol manifests benefits on survival in heart failure, but it is not evidence that carvedilol improves outcome over the formulation of metoprolol toprol xl with benefits in heart failure.

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