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Before taking this medication, tell your doctor if you are taking any of the following medicines antihistamines such as brompheniramine dimetane, bromfed, others , chlorpheniramine chlor-trimeton, teldrin, others , azatadine optimine , clemastine tavist , and many others narcotics pain killers such as meperidine demerol , morphine ms contin, msir, others , propoxyphene darvon, darvocet , hydrocodone lorcet, vicodin , oxycodone percocet, percodan , fentanyl duragesic , and codeine fiorinal, fioricet, tylenol 3, others sedatives such as phenobarbital solfoton, luminal , amobarbital amytal , and secobarbital seconal phenothiazines such as chlorpromazine thorazine , fluphenazine prolixin , mesoridazine serentil , perphenazine trilafon , prochlorperazine compazine , thioridazine mellaril , and trifluoperazine stelazine antidepressants such as doxepin sinequan , imipramine tofranil , nortriptyline pamelor , fluoxetine prozac , paroxetine paxil , sertraline zoloft , phenelzine nardil , and tranylcypromine parnate drugs other than those listed here may also interact.

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In placebo-controlled clinical trials patients receiving paroxetine experienced abnormal values on liver function tests at a rate equal to or less than that reported in patients receiving placeboHoweverthere have been postmarketing reports of patients developing elevated serum transaminases resulting in severe liver dysfunctionas well asa few cases of elevated liver function tests resulting in death secondary to liver necrosisRef]

The manufacturer directs not to chew/crush the tablet before taking itHowevermany similar drugsimmediate-release tabletscan be chewed/crushedFollow your doctor’s directions on how to take this medication.

Some products that may interact with this drug includethioridazineother drugs that can cause bleeding/bruisingincluding antiplatelet drugs such as clopidogrelNSAIDs such as ibuprofenblood thinnerssuch as warfarin

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