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Sinemet has a few side effects that may take a while to manifest, but which can become significant over time.

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Levodopa aloneas well as SINEMETis associated with dyskinesiasThe occurrence of dyskinesias may require dosage reduction.

As with levodopacare should be exercised in administering SINEMET to patients with a history of myocardial infarction who have residual atrialnodalor ventricular arrhythmiasIn such patientscardiac function should be monitored with particular care during the period of initial dosage adjustmentin a facility with provisions for intensive cardiac care.

SINEMET and iron salts or multivitamins containing iron salts should be coadministered with cautionIron salts can form chelates with levodopa and carbidopa and consequently reduce the bioavailability of carbidopa and levodopa.

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