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Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubulewhich are responsible for 1-2of total sodium reabsorptionAs sodium reabsorption is inhibitedthis increases the osmolarity in the nephron lumen and decreases the osmolarity of the interstitiumSince sodium concentration is the main driving force for water reabsorptiontriamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitiumTriamterene also has a potassium-sparing effectNormallythe process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorptionAs sodium is reabsorbedit leaves a negative potential in the lumenwhile producing a positive potential in the principal cellThis potential promotes potassium excretion through apical potassium channelsBy inhibiting sodium reabsorptiontriamterene also inhibits potassium excretion.

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The usual dose of MAXZIDE-25 MG is one or two tablets dailygiven as a single dosewith appropriate monitoring of serum potassiumsee WARNINGSThe usual dose of MAXZIDE is one tablet dailywith appropriate monitoring of serum potassiumsee WARNINGSThere is no experience with the use of more than one MAXZIDE tablet daily or more than two MAXZIDE-25 MG tablets dailyClinical experience with the administration of two MAXZIDE-25 MG tablets daily in divided dosesrather than as a single dosesuggests an increased risk of electrolyte imbalance and renal dysfunction.

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